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Re: mrsa in knee replacement
Reply #20 by Michael
Posted: December 5, 2006 at 04:09
I have been through hell and back and then some with my 9 knee (yes 9) in 5 years with 2 staph infections ending in a TNR. I will tell you I have felt like a test leg to see how much PAIN I can take. # 1 Make sure the doctor is patient enough with you. I felt like a number going through each process and felt the Dr's were under pressure to get in as many TNR they could each day. My Dr. went on vacation the day after my operation and after I call his office they said to see what happens in a day or 2. Well, Day 3 my knee was the size of a medicine ball. I contacted my doctor hundreds of miles away. He contacted an other Dr. to come and clean the infection. I had to sit in the hall of a hospital for 5 hours with an open wound that I'm sure got worse by the minute.
Now year 5 into my knee problem and after the drug addiction and Therpy, my leg still swells up and I am limited in everything I do. If you have a story to pass on with the realities of what can happen in a Doctors care please let the public know to make sure the doctors don't rush to their decisions. I would have never had the 1st operation if I knew the end results I have today.

Please be CAREFULL...

A sore man in NYC
Re: mrsa in knee replacement
Reply #21 by vpmoe
Posted: December 19, 2007 at 10:58
i have had 4 operations on my left knee after 6 wks of ivs they put in the knee last dec.12th now the infection is back i will see an infectis dr. tomarrow I just dont know what to do. HELP
Re: mrsa in knee replacement
Reply #22 by Nancy R
Posted: December 19, 2007 at 14:50
Well, I may be the exception to the rule, but I am happily recovering from a year from Hell. I finally, after 4 hip replacement surgeries, am walking just fine and feeling very well. I have contracted HA MRSA in February, 2007 and had to have the implant removed. I did have an impregnated spacer installed and successful hip replacement surgery in September. I have had no complications post op. I actually barely remember that I had my hip replaced now. Its working very well.

I was treated with Zyvox (unsuccessful) for two rounds of IV dosing. Ultimately, I was given Cubicin (IV) and Bactrin (orally) and finally stopped the advancing MRSA. I have had 3 blood tests since my September surgery and all appear to be clear. I think you MUST have Cubicin and Bactrin given simultaneously for the proper outcome. When I had only Cubicin, the infection returned. When combined with Bactrin, it ended.

I am highly allergic to Vancomycin and that was never an option for me.
Re: mrsa in knee replacement
Reply #23 by Carole
Posted: January 1, 2008 at 04:47
In preparing for a total knee replacement, I had nose and groin swabs to check for mrsa. the nose swab came back positive. Now i will have to do 2 weeks of antibiotics prior to surgery. anyone else familiar with this situation. i am 46 and want to have a successful operation the first time...
Re: mrsa in knee replacement
Reply #24 by cr
Posted: February 28, 2008 at 04:16
I never thought of having the swabs done. My father in law has been living with a MRSA infection in the hardware in his right knee replacement after having a planter wart removed. He almost died in hospital & between hospital and rehab-where he received Vancomycin IV-he spent4 1/2 mos. He has been home since Jan. 07. His knee was drained several times in the last year. He has been pretty active & drives & goes to a gym 3x a week. He tends to be nauseous a great deal of the time. Sometimes he will eat & then throw up. Usually he feels better afterward. Since I had an aunt & grandmother die from MRSA, I have been very watchful with the father in law. He takes Bactrim, oral, 800mgs twice/day along with Celebrex & Nexium. We don't know how long he can keep going, because of the nausea, but he is setting records every day.
Re: mrsa in knee replacement
Reply #25 by Kory
Posted: March 8, 2008 at 07:04
I got mrsa 4 years ago, went on several antibiotics, 2 yrs ago I had a knee replacement, my legs are swollen from the knees down and my doctors keeps sending me to other specialists. I've had ultrasound done on my legs and my veins are clear. What type of specialist should I go to?
Re: mrsa in knee replacement
Reply #26 by Maria
Posted: March 9, 2008 at 16:17
Dear Kory
Has your doctor sent you to an orthopeadic specialist? They are subject to mandatory reporting of surgical site infections. If you need more surgery then you should be able to get information on orthopeadic infection rates for hospitals in your area, these are available on the Health Protection Agency website, if you need more details then please post here.
Re: mrsa in knee replacement
Reply #27 by Carolyn
Posted: March 21, 2008 at 23:08
Please help.
My Mom has MRSA from a knee replacement. She has been on antibiotics for months now, including weeks of I.V. antibiotics, (cubicin), vancomycin. Now she is on doxycycline. She is sick from this constantly. The incision seems to heal over, then it swells and begins to leak copious amounts of fluid. Her surgeon drains it, then the process begins again. The possiblity of losing her leg has been mentioned, and she has been told that the infection exists 'inside the prosthesis'. How is this possible, the prosthesis not being made of tissue? Also, are we using the most current antibiotic therapy available? I hear about 'phage' therapy. Is that currently available? Any new antibiotics approved for use that we don't know about? My Mom said that she heard something on the news, but didn't remember the name. If we have the prosthesis permanently removed, how is the leg connected? Will she be able to bend it again, ever? The possibility of another knee replacement just isn't an option. This is her 3rd or 4th one on that knee alone. We are just heartsick about this. Please help with anything that you know....................
Re: mrsa in knee replacement
Reply #28 by Nancy R
Posted: March 22, 2008 at 06:34

She must have the replacement removed. It has become a breeding ground for MRSA. What is likely happening is that inside the bone, the colonies are growing and the antibiotics cannot control the numbers. I'm certain that your mother's immune system is also compromised from all of the antibiotics. I, also, was on Cubicin, Zyvox and Bactrin with mixed results.

Once the implant was removed, an imbedded spacer was inserted for 10 weeks as I was given IV Cubicin and oral Bactrin to control the MRSA. It worked. I am now happy to report that my hip is doing very well. I am just now about to hit the 6 months anniversary. However, unfortunately for me, my right knee has deteriorated so badly from overuse and arthritis, I must now have that replaced in April of this year. If I don't, I'll spend the rest of my life in a wheelchair. The calf muscles are starting to constrict now and I'm currently using a special stretching brace to prepare for surgery. I am very concerned about the possibility of MRSA recurring, but I have to take this chance. I am 58 years old and up until last year, I was in excellent health. Now that my hip is fixed, I feel very cheated. It's like winning a new car, but not having a driver's license!
Re: mrsa in knee replacement
Reply #29 by sharon
Posted: April 9, 2008 at 03:04
I have had 4 knee operations on the left knee, I am now getting redy for a total knee revision . I have been on Daptomycin IV for 6 weeks. I am very worried. Can anybody give me some advise?
Re: mrsa in knee replacement
Reply #30 by Barbara Borkowski
Posted: May 18, 2008 at 20:35
My husband had a knee replacement several years ago without incident. He is 55 years old. Last July, he had a knee replacement operation that has turned into a nighmare because of MRSA. He has been in extreme pain. He has had six operations since then. We changed physicians because the first physican did a poor job inserting the replacement (took way to long and he admitted he had never worked with a replacement that large). The reason I am writing to you is that the doctors have now decided to put my husband on Daptomycin. The infectious disease doctors are most optimistic about this drug. I would very much like to keep in contact with you since you and my husband will be on the same medication. It could be very helpful to share experiences. Best wishes to you.
Re: mrsa in knee replacement
Reply #31 by Diana
Posted: July 4, 2008 at 12:08
MRSA - Methacillin Resistant Staphoreous is resistant to penicillin and most major antibiotics. It is a super infection that is very difficult to treat. As mentioned in some of these comments, Vancomycin, Daptomycin, Bactrim etc are the best forms of treatment. It is verulant - very difficult to kill. Just one bacteria can cause you to be reinfected.

Daptomycin has been shown to be the best treatment for MRSA. Unfortunately, my husband has had 7 surgeries and one bone cement implant on his left knee but is reinfected again. He is tired of surgery and is planning a arthroplasty - where they permanently fuse the bones between the knee together

remember the #1 way to prevent infection is to wash your hands.
MRSA in hardware
Reply #32 by Brenda
Posted: July 25, 2008 at 22:45
Last June I had a horseriding accident and ended up with a spiral fracture of my tibia/fibula. This was treated with a plate, many screws and bone grafts. In September I ended up with MRSA osteomylitis of the leg. I was treated with IV vanco and rifampin for about 7 weeks. During that time I also became septic from my PICC line so we had those issues to deal with also. Oh yes, and blood clots in my leg with required me to be on coumadin. Not a fun 6 months for me!! anyhow, I have been to see an ID specialist who wants me to take doxycycline. He says I will be on it "forever or until your metal is out". I of ocurse am scared to death of another surgery. I am an RN (probably why I got MRSA in the first place) and know that I could potentially end up without a leg or worse. At this point I am back to work, feel good and have started riding again. I guess I'm looking for a long term success story!! My fracture was so bad that without the hardware I will not walk for a very long time if ever. I have also seen an orthopedic trauma surgeon who comes highly recommended who tells me I have a 25% chance of reinfection if I don't have it taken out. So to me that says a 75% chance of being ok. Is there anybody out there who has retained their hardware and done ok?
Re: mrsa in knee replacement
Reply #33 by Jeannie
Posted: September 8, 2008 at 21:49
I had my knee replaced almost 4 yrs. ago. I now have MRSA on the same leg on my thigh. I am on cephalexin and bactrim but I failed to mention my knee. The infection is looking better after 4 days but my knee is slightly swollen. Should I worry?
Re: mrsa in knee replacement
Reply #34 by John Bishara
Posted: March 27, 2009 at 15:04
I have been diagnosed as having MRSA in my left knee, which is artificial. I contracted this infection April 29, 2008 during a same day procedure to clear an artery in my left leg, just below the artificial knee. I have been taking antibiotics daily ever since. I was taking Keflex 500 mg. twice daily until a week ago when my left knee developed a swelling on right side of knee cap. The swelling was aspirated, a culture grown and the result was MRSA. My doctor switched me from the Keflex to Bactrim DS twice daily and Rifampin 300 mg. twice per day. My doctor tells me this infection is harbored in the artificial knee and they want to remove the knee, put in an antibiotic spacer for 6-8 weeks while I will also be on antibiotic IVís. When this is done they plan to install a new knee.
I contracted this infection on April 29, 2008, spent the month of may in ICU where I almost died twice, etc, etc.. Is the planned procedure I mentioned above the best way to get rid of this infection? Quite frankly, after all I have been through, Iím trying to avoid surgery, nursing homes and all associated pain, plus the possibility of getting more MRSA or C-Diff. Is there a better safer route to take?

Presently, I feel fine, exercise daily including riding my bicycle.

John Bishara

Re: mrsa in knee replacement
Reply #35 by Nancy R
Posted: March 30, 2009 at 02:29

Daptomycin is also called Cubicin. I was eventually cured by having the hardware removed, the bones cleaned, and a spacer installed for 10 weeks. During that time, a PICC line was installed and I infused Cubicin 2 times a day and did oral Bactrin daily. This was for a hip.

It worked for me. Zyvox did not and I was too allergic to Vancomycin to even give that a try.

I have had no recurrent MRSA for 20 months and I also had a knee replacement within that time frame. No more MRSA.
Re: mrsa in knee replacement
Reply #36 by connie
Posted: April 18, 2009 at 05:05
my grandmother had a total knee replacement last year. Everything was healing and the dr said she was fine. 3 months after the surgery she had swollen of the knee which dr aspirated the site and pus came out and dr took sample, sample came back with staph infection. Dr did another surgery to clean and put new screws in knee. 6 weeks went by and infection came back. Dr did another surgery and to remove everything in the knee and put a spacer in knee now they say she has mrsa. she has has numuerios pic lines for antibotics. I not understanding why is this still going on with infection in the knee.
How did infection get in the knee when the wound site was healed and no redness around it. Thank you in advance.
Re: mrsa in knee replacement
Reply #37 by linda
Posted: April 22, 2009 at 15:27
i had mrsa a year ago and now am suppose to have hip replacement and scared of the mrsa returning

Re: mrsa in knee replacement
Reply #38 by annette
Posted: April 23, 2009 at 16:36
Ive been diagnosed with mrsa about 2 months ago,however i have had the symptoms for 2 years.
During this time i have been on several courses of antibiotics, I just finsished my last course (2 months) 2 weeks ago, my symptoms have started up again, its so frustrating!
So I called my gp, so he is going to put me onto another course of antibiotics, I don't understand, surely this can't be the only cure.
Its bad enough that its almost taken them 2 years to discover i infact have mrsa, so why aren't they tring other methods?
How long am I supposed to suffer?
Re: mrsa in knee replacement
Reply #39 by Bill
Posted: April 26, 2009 at 22:42
I had a total knee replacement in '96.I started kidney dialysis in '97. I had a kidney transplnt in 2000,and I got MRSA in a perm. cath. after they lowered my immunity with Prednesone.The mrsa went to my knee replacement .They tried flushing my knee with saline and gave me antbiotics.After 19 days in hosp. they sent me to the dr. that put the knee in. That DR. removed the hardware,put in spacer,started vanc.for 6 weeks,stopped for 4 wks. and mrsa was still there.The Dr. repeated this procedure again , and the mrsa was still there .So another surgeon was brought into fuse the leg straight . This took 8 hours to clean the infection out and install a device called a Lizeroth to hold my leg straight while it fused together .It had 13 screws that went into my leg bones that had to be cleanned every day. This device is also used on kids to lenghten their legs.This made my leg 2" shorter than it was because of the space the hardware had taken up and the leg will not bend.My Doctors at that time(2001)told me I could never have another knee replacement because the mrsa could come back and cause me to lose my kidney transplant . I am still mrsa free , my transplant is better than it was to start with, thank the Lord . BUT my other knee is now bone to bone and the Dr. that fused my rt. leg wants to install a total knee replacement in the left knee. I don't know if he just needs the money or can the procedure be done safely. I guess I need a second opinion.
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